The Lady's Secret Stakes (formerly the Zenyatta Stakes and Lady's Secret Breeders' Cup Handicap) is an American Thoroughbred horse race run annually near the end of September during the Oak Tree Racing Association meet at Santa Anita Park in Arcadia, California. The race was run at Hollywood Park in 2010 due to impending work at Santa Anita Park. There is also an east coast version run at Monmouth Park.

A Grade I event since 2007, it is open to fillies and mares, age three and older, willing to race one and one-sixteenth miles. In November 2010, the race was renamed after the 2009 Breeders' Cup Classic winner and 2010 American Horse of the Year Zenyatta, who won the race in 2008, 2009 and 2010. The race was previously named after the great Hall of Famer Lady's Secret. In the top 100 U.S. thoroughbred champions of the 20th Century, Lady's Secret is ranked #76. Although the name of the race was changed to the Zenyatta Stakes, that change was held off for 2010 at the behest of the connections of Zenyatta. For 2010, it was again run as the Lady's Secret Stakes because Zenyatta was in the field. The Mosses and Zenyatta's trainer, John Shirreffs, requested that the race be changed back to its original name for this running. The race name change was done on the assumption that Zenyatta would retire at the end of 2009. The Hollywood Park officials did not anticipate that she might again race in the Lady's Secret in 2010.