The San Gabriel Handicap is an American Thoroughbred horse race run at Santa Anita Park in Arcadia, California. The Grade II race is open to horses, age three and up, willing to race one and one-eighth miles on the turf and offers a purse of $150,000. First run in 1935, it was contested on dirt through 1954. Since inception, the San Gabriel Handicap has been contested under various conditions and distances.

The race has been contested twice in six of its years: in January and then again in December 1973, 1980, 1988, 1997, 2001, and 2006. It was run in two divisions in 1984. The race was transferred to the dirt track in 1972, 1974, 1977, 1978, 1987, December 1988, 2005 and 2008. There was no race in 1936, 1939-1944, 1947-1951, 1970, 1976, 1982, 1991, 1999 and 2004.