The Vinery Madison Stakes is an American Thoroughbred horse race run annually in early April at Keeneland Race Course in Lexington, Kentucky. Contested on Polytrack synthetic dirt over a distance of seven furlongs, it is open to fillies and mares, age four and older.

Inaugurated in 2002 as the Madison Stakes, in 2005 the event was upgraded from a Listed race to Grade III status then in 2006 to Grade II. It was upgraded in 2009 to a Grade I event.

The race is named for Madison County, the largest county in the Bluegrass region of Kentucky. In 2004 the name of the race was amended to add the name of its new sponsor, Vinery, a local Thoroughbred breeding operation.