Santa Anita Oaks is an American Grade I Thoroughbred horse race held annually, typically run in mid March, at Santa Anita Park in Arcadia, California. Open to three-year-old fillies willing to race 8.5 furlongs (1 1/16 miles) on the dirt, it currently offers a purse of $300,000.

Inaugurated in 1935 as a race for two-year-olds, it originated as the Santa Susana Stakes. In 1952 the race became the Santa Susana Handicap then in 1958 reverted to the Santa Susana Stakes. In 1986 it was given its current designation as the Santa Anita Oaks. Since inception, the race has been set at various distances.