The Santa Barbara Handicap is an American Thoroughbred horse race run annually in mid April at Santa Anita Park in Arcadia, California. A Grade II event open to fillies and mares, age four and older, it is contested of turf over a distance of one and a quarter miles.

Inaugurated in 1935, through 1941 it was a race for two-year-olds. In 1952 and again in 1954 it was restricted to three-year-old California-foaled fillies and in 1953 for three-year-old California foals of either sex. From 1955 through 1965, it was open to horses age three-year-olds and up and then since 1966 for fillies and mares age four and older.

The race was known as the Santa Barbara Juvenile Championship in 1937 and then as the Santa Barbara Stakes in 1935 and 1936, 1938, 1941, 1946 and 1952 through 1954. Since inception it has been contested at a variety of distances. In 1968, the race was run at "about" distance. In 1973, 1977 and 1982, it was run on dirt. It was run in two divisions on three occasions: 1941, 1967, 1968. There was no race run in 1939, 1940, 1942 through 1945, 1947 through 1951 and 1959 through 1961.